Pronamel Science: Acid-weakened enamel surfaces can be repaired

Actively repair acid-weakened enamel with this unique formulation1,2

A unique formulation for patients with early acid erosion

Pronamel Intensive Enamel Repair contains sodium fluoride (1450 ppm) and 5% w/w potassium nitrate, as well as ingredients that can enhance the activity of fluoride to promote remineralisation and inhibit demineralisation. These include:

  • Adding lactate and controlling pH to promote fluoride uptake3,4
  • Adding a co-polymer that helps lock-in minerals, making enamel more resistant to future acid attack5
Remineralisation / demineralisation cycle

A formulation that actively repairs

The unique Pronamel Intensive Enamel Repair formulation works to promote enamel remineralisation by delivering more fluoride deep into acid-weakened enamel surfaces*2 and helps protect against acid eroision6 (inhibits demineralisation) with its low abrasivity and fluoride protection formula.

*vs two competing toothpastes.

Pronamel Intensive Enamel Repair Actively repairs acid-weakened enamel1,2

  • Promotes fluoride uptake to repair acid-weakened areas of enamel surface in vitro1

    SEM of fluoride uptake

    In vitro cross-sectional DSIMS images of enamel surface to compare penetration of fluoride with Pronamel Intensive Enamel Repair vs. two competing toothpastes.1

    Adapted from GSK data on file 18005. *vs two competing toothpastes. **Regenerate Original Advanced Enamel Science (1450 ppm fluoride as sodium monofluorophosphate). Sourced in March 2018. ***Oral B Pro-Expert Gum & Enamel Repair (1100 ppm F as stannous fluoride, 350 ppm F as sodium fluoride).

  • Promotes fluoride uptake to repair weak areas of the enamel surface in an in situ clinical study2

    Enamel fluoride uptake

    Enamel fluoride uptake was significantly higher with Pronamel Intensive Enamel Repair vs. a competitor toothpaste and placebo (p<0.0001), as shown in a single centre, controlled, examiner-blind, randomised, three-treatment, three-period, crossover in situ design to test the remineralising performance of dentifrices.Treatment was provided once and assessed 2 and 4 hours after application. A washout phase of 2 days (using a fluoride-free dentifrice) was implemented prior to each treatment visit.2

    EFU, Enamel Fluoride Uptake. Adapted from GSK Data on file 208166. *Pronamel Intensive Enamel Repair (1150 ppm F) vs. Crest ProHealth Sensitivity and Enamel Shield (1100 ppm F as stannous fluoride).

  • Promotes remineralization of acid-weakened enamel surfaces in an in situ clinical study2

    Surface micro-hardness recovery (SMHR)

    SMHR was significantly higher with Pronamel Intensive Enamel Repair vs. a competitor toothpaste and placebo (p<0.0001).2 This was shown in a single-centre, controlled, examiner-blind, randomised, three-treated, three-period, cross-over in situ design to test the remineralising performance of dentrifices. Treatment was provided once and assessed 2 and 4 hours after application. A washout phase of 2 days (using a fluoride-free dentrifice) was implemented prior to each treatment visit.2

    SMHR, surface micro-hardness recovery. SMHR measures the increase in hardness of the enamel surface due to mineral uptake i.e. remineralisation, after product use. Adapted from GSK data on file 208166. *Pronamel Intensive Enamel Repair (1150ppm F) vs. Crest ProHealth Sensitivity and Enamel Shield (1100 ppm F as stannous fluoride).

  • Helps inhibit demineralisation to protect against enamel wear due to acid erosion in vitro 6

    3-dimensional profilometry (3DP) analysis of human enamel specimens

    In a 3DP analysis of human enamel specimens to measure the loss of material (step height) between tape-protected and exposed regions of the enamel following a brushing treatment, brushing with Pronamel Intensive Enamel Repair resulted in protection from tissue loss due to demineralisation and surface wear vs. two competitors.6

    Adapted from GSK data on file 181023.*vs two competing toothpastes. **Regenerate OriginalAdvanced Enamel Science (1450 ppm fluoride as sodium monofluorophosphate) Sourced in March 2018. ***Oral B Pro-Expert Gum & Enamel Repair (1100 ppm F as stannous fluoride, 350 ppm F as sodium fluoride).

  • Inhibits demineralisation to help protect against acid erosion in an in situ clinical study2

    Relative Erosion Resistance with Pronamel Intensive Enamel Repair

    In a single centre, controlled, examiner-blind, randomised, three-treatment, three-period, cross-over in situ design to test the remineralising performance of dentifrices***, Pronamel Intensive Enamel Repair demonstrated significantly superior prevention of demineralisation as evidenced by % RER vs. a competitor and placebo (p<0.0001).2

    RER, Relative Erosion Resistance; measures whether the dentifrices provide a combined benefit in terms of enhanced remineralisation and acid resistance of the enamel.Adapted from GSK Data on file 208166. *vs a non-optimised fluoride toothpaste. **Pronamel Intensive Enamel Repair (1150 ppm F) vs. Crest ProHealth Sensitivity and Enamel Shield (1100 ppm F as stannous fluoride). ***Treatment was provided once and assessed 2 and 4 hours after application. A washout phase of 2 days (using a fluoride-free dentifrice) was implemented prior to each treatment visit.

Pronamel Intensive Enamel Repair Toothpaste

Pronamel Intensive Enamel Repair Toothpaste

A unique, specialist toothpaste for patients with early signs of acid erosion

Sensodyne Pronamel – helping protect your patients against enamel wear

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